King Charles III, the Princess of Wales, who died in 1997, Prince William and Prince Harry are among those to have visited the Steel City over the years.
The late Queen and Queen Mother also visited.
We have put together a gallery looking back at some of those visits to the city over the years.
Our picture gallery shows visits over the last five decades.
17. Royal
Staff introduce patient Peter Beer, aged 6, of the Manor, Sheffield, to Princess Margaret during a tour of Sheffield Children's Hospital in 1976 Photo: Sheffield newspapers
18. Princess Alexandra, The Queen's cousin, chats to nurses on a visit to the Northern General Hospital, Sheffield in 1982
Princess Alexandra, The Queen's cousin, chats to nurses on a visit to the Northern General Hospital, Sheffield in 1982 Photo: Sheffield Newspapers
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