King Charles III, the Princess of Wales, who died in 1997, Prince William and Prince Harry are among those to have visited the Steel City over the years.
The late Queen and Queen Mother also visited.
We have put together a gallery looking back at some of those visits to the city over the years.
Our picture gallery shows visits over the last five decades.
1. Princess Diana at Jessop Hospital July 1991
Princess Diana at Jessop Hospital July 1991 Photo: Barry Richardson
2. Harry at the Children's
Prince Harry, Duke of Sussex plays with one year old Noah Nicholson, during a visit to Sheffield Children’s Hospital on July 25, 2019 in Sheffield, England. (Photo by Chris Jackson/Getty Images) Photo: Chris Jackson
3. Prince Charles
Prince Charles chats to patients and staff in the Sports Hall at Lodge Moor Hospital, Sheffield - 9 June 1987 Photo: Sheffield Newspapers
4. Weston Park Hospital
Princess Anne at the official opening of Weston Park Hospital, Sheffield - 1st July 1970 Photo: Sheffield Newspapers