King Charles III, the Princess of Wales, who died in 1997, Prince William and Prince Harry are among those to have visited the Steel City over the years.
The late Queen and Queen Mother also visited.
We have put together a gallery looking back at some of those visits to the city over the years.
Our picture gallery shows visits over the last five decades.
5. Mascot
Prince Harry, Duke of Sussex meets the hospital's mascot, Theo the bear, during a visit to Sheffield Children’s Hospital on July 25, 2019 in Sheffield, England. (Photo by Chris Jackson/Getty Images) Photo: Chris Jackson
6. Visitor
Prince Harry, Duke of Sussex speaks with 11 year old Heath Keighley during a visit to Sheffield Children’s Hospital on July 25, 2019 in Sheffield, England. (Photo by Chris Jackson/Getty Images) Photo: Chris Jackson
7. Diana
Photographs of Princess Diana visiting the hospital 30 years ago were seen during Prince Harry, Duke of Sussex's visit to Sheffield Children's Hospital on July 25, 2019 (Photo by Chris Jackson/Getty Images) Photo: Chris Jackson
8. Opening ceremony
The Children's Hospital, Sheffield, new wing opened by Her Royal Highness, the Princess of Wales on 29th November 1989 Photo: Sheffield Newspapers