As things stand, the Blades are seventh in the table, just two points ahead of Forest in ninth, and the result game could go a long way in deciding whether either of the two sides makes the top six.
The last time the two sides faced each other, back in November, United secured a 1-1 draw away from home, with Morgan Gibbs-White getting on the scoresheet.
Ahead of the game, United manager Paul Heckingbottom has given his verdict on misfiring striker Oli McBurnie, who has scored just one in his last 36 matches for the Blades.
Heckingbottom said: "With Oli, it’s game time. If you get him on the pitch, then he’ll score goals and his record tells you that. It proves that. But I can’t leave him on the pitch just to score goals.
“I’m not concerned about Oli, because I see him every single day in training. All he can keep doing is fighting and knuckling down. Because eventually a chance will drop for him and he’ll tuck it away.
"Then, when that happens, we’ll all be talking about something different won’t we. The story will change.”
Take a look at the latest news and transfer stories from the second tier, ahead of another busy midweek packed with fixtures:
9. Blades brace for Lowe bid
Officials at Sheffield United are said to be “convinced” for a move for defender Max Lowe from Nottingham Forest before the window opens again in the summer. The £3.5m man has impressed on with the club this season, making twenty appearances on the left flank. (The Star) | Getty Images
10. European giants eye Spence
Bayern Munich are said to have joined the race to sign Middlesbrough youngster Djed Spence. He’s been a key figure during a loan spell for Nottingham Forest this season, and has been tipped for a big move this summer. (Sky Sports) | Getty Images