As things stand, the Blades are seventh in the table, just two points ahead of Forest in ninth, and the result game could go a long way in deciding whether either of the two sides makes the top six.
The last time the two sides faced each other, back in November, United secured a 1-1 draw away from home, with Morgan Gibbs-White getting on the scoresheet.
Ahead of the game, United manager Paul Heckingbottom has given his verdict on misfiring striker Oli McBurnie, who has scored just one in his last 36 matches for the Blades.
Heckingbottom said: "With Oli, it’s game time. If you get him on the pitch, then he’ll score goals and his record tells you that. It proves that. But I can’t leave him on the pitch just to score goals.
“I’m not concerned about Oli, because I see him every single day in training. All he can keep doing is fighting and knuckling down. Because eventually a chance will drop for him and he’ll tuck it away.
"Then, when that happens, we’ll all be talking about something different won’t we. The story will change.”
Take a look at the latest news and transfer stories from the second tier, ahead of another busy midweek packed with fixtures:
5. Battle for Semenyo intensifies
RB Salzburg are the latest side to be credited with an interest in an interest in Bristol City striker Antoine Semenyo. He’s bagged six goals and made eight assists so far this season, which has seen him also attract interest from Celtic and West Ham. (FootballScotland) | Getty Images
6. Forest could bring Garner back if promoted
Nottingham Forest’s hopes of bringing star loanee James Garner back for another season could rest upon whether they can secure promotion. Man Utd are said to be hopeful of the player gaining top tier experience on loan next season. (The Athletic) | Getty Images
7. Forest star in no rush over future decision
Nottingham Forest sensation Brennan Johnson is said to be in “no rush” to sign a new deal. The Forest star has attracted interest from the likes of Leeds United, West Ham and Brentford, and looks likely to keep his future options open. (The 72) | Getty Images
8. Saints keen on Terriers loan man
Southampton are believed to be interested in signing Chelsea midfielder Tino Anjorin. He’s currently on loan at Huddersfield Town, but hasn’t featured since joining last month due to injury issues. (Evening Standard) | Getty Images