The Owls are now looking to appoint their third manager of the campaign in an effort to find some much-needed stability and avoid becoming embroiled in a relegation battle towards the tail-end of the season.
Here's our rundown of SkyBet’s latest front-runners who could become the next Sheffield Wednesday manager.
5. Neil Thompson - Current odds: 18/1
Current job: Sheffield Wednesday caretaker. Career win percentage: 28% (Photo by George Wood/Getty Images) Photo: George Wood
6. Mick McCarthy - Current odds: 16/1
Current job: Unemployed. Last job: APOEL Nicosia. Career win percentage: 38.8% (Photo by Catherine Ivill/Getty Images) Photo: Catherine Ivill
7. Gus Poyet - Current odds: 14/1
Current job: Unemployed. Last job: Bordeaux. Career win percentage: 42.7% (Photo by MEHDI FEDOUACH/AFP via Getty Images) Photo: MEHDI FEDOUACH
8. Joey Barton - Current odds: 12/1
Current job: Unemployed. Last job: Fleetwood Town. Career win percentage: 39.8% (Photo by Pete Norton/Getty Images) Photo: Pete Norton