The Blades have shown signs of clicking into gear after a difficult start to the season, with Chris Wilder's side initially struggling to recover from the summer departures of Callum O'Hare, Gus Hamer and Andre Brooks.
O'Hare will be back in South Yorkshire for the first time since his deadline-day move to Wrexham, with the visitors arriving 17th in the Championship after a challenging start to life in the second tier.
Patrick Bamford could keep his place despite coming off with a shoulder issue last weekend against Derby County but Ryan One is still out after suffering a recurrence of the hamstring injury that kept him out for most of the season.
Here’s the side we’d pick to face the Red Dragons - have we got it just about right or would you do anything differently?
1. Michael Cooper
Kept United in the game with a couple of first-half saves and that enabled them to earn a point later on when they finally got going. First name on the teamsheet and not just because he’s the No.1 | Jason Brown
2. Hamza Choudhury
Seriki’s return is a welcome one but I’d be loathe to chuck him in before he’s completely ready and so I suspect it’ll be another cameo off the bench before he gets up to full speed
3. Japhet Tanganga
He and whoever partners him will have to be alert against the physical threat of Kieffer Moore and, if he gets the nod to start alongside him, Sam Smith. He and Kitching are on four bookings too so have to be careful | Sportimage
4. Liam Kitching
I’ve been impressed with the Coventry loan man since he came into the building and he’s struck up a decent partnership with Tanganga which hopefully doesn’t get broken up by suspension anytime soon. The tightrope walking won't curb his natural competitiveness though | Getty Images