The Blades have shown signs of clicking into gear after a difficult start to the season, with Chris Wilder's side initially struggling to recover from the summer departures of Callum O'Hare, Gus Hamer and Andre Brooks.
O'Hare will be back in South Yorkshire for the first time since his deadline-day move to Wrexham, with the visitors arriving 17th in the Championship after a challenging start to life in the second tier.
Patrick Bamford could keep his place despite coming off with a shoulder issue last weekend against Derby County but Ryan One is still out after suffering a recurrence of the hamstring injury that kept him out for most of the season.
Here’s the side we’d pick to face the Red Dragons - have we got it just about right or would you do anything differently?
9. Tahith Chong
With One out it’s two from three for Wilder in terms of his wingers, unless he goes with a back three anyway, and Donovan and Chong get the nod for me | Sportimage
10. Patrick Bamford
Fit despite a concerning whack to his shoulder last weekend when he scored against Derby and assuming that’s not a bit of kidology from Wilder, he’d keep his place
11. Tom Cannon
A decent cameo off the bench from Tyrese Campbell last weekend should have resulted in a goal and will have given Wilder more food for thought, but Cannon seems to be the first-choice pick in that stretch role and it’ll be interesting to see if that continues against the Red Dragons | Sportimage