The Blades have shown signs of clicking into gear after a difficult start to the season, with Chris Wilder's side initially struggling to recover from the summer departures of Callum O'Hare, Gus Hamer and Andre Brooks.
O'Hare will be back in South Yorkshire for the first time since his deadline-day move to Wrexham, with the visitors arriving 17th in the Championship after a challenging start to life in the second tier.
Patrick Bamford could keep his place despite coming off with a shoulder issue last weekend against Derby County but Ryan One is still out after suffering a recurrence of the hamstring injury that kept him out for most of the season.
Here’s the side we’d pick to face the Red Dragons - have we got it just about right or would you do anything differently?
5. Harrison Burrows
Another welcome returnee on the left and he gets the shirt for me at the minute over McCallum, but that’s a tight battle and I wouldn’t be surprised at all if a change is made | Sportimage
6. Kalvin Phillips
Winning the midfield battle could be key against Wrexham and Phillips may come up against former teammate Callum O’Hare if he drops deep as usual and the former Blade floats around behind the front two | Sportimage
7. Sydie Peck
Oliver Arblaster has had the shirt in recent weeks but I wonder if Peck may get a recall after starting on the bench for the last couple of games. That’s no slight on Arblaster, though | Getty Images
8. Romelle Donovan
Surely has to start after his cameo off the bench on Saturday? That’s the will of many supporters anyway and for me he starts over Brereton Diaz | Sportimage