The Blades are looking for back-to-back wins for the first time this season after beating Wrexham on Friday night and are also looking to pile the misery on North End after their torrid start to the new season.
United will be without Liam Kitching as he serves a one-match ban after picking up his fifth booking of the season on Friday but hope to welcome back Patrick Bamford after a shoulder issue.
Chris Wilder is also keeping his fingers crossed that Kalvin Phillips will be fit to keep his place after suffering an ankle injury against the Welshmen.
Here’s the side we’d pick to face North End - have we got it just about right or would you do anything differently?
1. Michael Cooper
Cooper looks certain to keep his place between the posts at Deepdale. He could have been sat with us in the press box against Wrexham and will hope for another serene evening this time out | Jason Brown
2. Hamza Choudhury
With Seriki not yet fit to start, according to boss Wilder pre-game, Choudhury is expected to continue at right-back, where his defensive discipline offers United a solid option. He will have to be switched on against Preston's threat down the flanks with Seriki expected to get some action off the bench again later on
3. Japhet Tanganga
Tanganga will keep his place at the heart of the defence, barring any unforeseen circumstances. His physicality and ability to deal with direct balls will be important against a Preston side looking to get their forwards involved early as they eye a season-starting win | Sportimage
4. Mark McGuinness
With Liam Kitching suspended after picking up his fifth booking against Wrexham, McGuinness could come into the side alongside Tanganga. Baptiste and McCallum are other options but McGuinness came off the bench on Friday and appears to be the next cab off the rank | Sportimage