The Blades are looking for back-to-back wins for the first time this season after beating Wrexham on Friday night and are also looking to pile the misery on North End after their torrid start to the new season.
United will be without Liam Kitching as he serves a one-match ban after picking up his fifth booking of the season on Friday but hope to welcome back Patrick Bamford after a shoulder issue.
Chris Wilder is also keeping his fingers crossed that Kalvin Phillips will be fit to keep his place after suffering an ankle injury against the Welshmen.
Here’s the side we’d pick to face North End - have we got it just about right or would you do anything differently?
9. Tahith Chong
On the other wing Chong’s ability to carry the ball and take on defenders would give United another route into the final third against the league’s bottom side | Sportimage
10. Ben Brereton Diaz
Scored his first goal of the season last time out and that will have been a timely boost for the forward, who will be keen to build on it and add more going forward. With Bamford a doubt I’ve kept him further forward, which allows Donovan into the side
11. Tom Cannon
Only came off the bench on Friday but could come into the side to provide a different attacking option alongside Brereton Diaz. His movement and willingness to run in behind could give Preston's defence something different to deal with, with Campbell another option. Ayew only doesn’t start in my side because of his age and the quick turnaround from Friday | Sportimage