From churches to pubs, nightclubs and sports venues, many notable landmarks across the city have been consumed by flames.
This retro photo gallery looks back at those sites, showing them before and after the fires struck.
Most of these landmarks were so badly damaged that they had to be demolished, while in other cases the charred shell was left standing, open to the elements.
The fires that destroyed these buildings include the largest ever peacetime conflagration in Sheffield, which broke out beside the railway tracks more than a century ago.
These nostalgic images show the lost landmarks inside and out, revealing the beautiful architecture and stunning interiors that are sadly no longer.
How many of these old landmarks do you remember?
9. St Bartholomew's
St Bartholomew's Church, on Attercliffe Common, Sheffield, in 1969, after it was destroyed by fire | Picture Sheffield/Sheffield Newspapers Ltd Photo: Picture Sheffield/Sheffield Newspapers Ltd
10. Albert Hall
Albert Hall, on the corner of Barker's Pool and Burgess Street, Sheffield city centre, in 1932. It opened in December 1873 as a concert hall, began showing short films on a regular basis, and from June 1918 operated as a normal cinema. It was destroyed by fire on July 14, 1937. | Picture Sheffield
11. Theatre Royal
The shell of The Theatre Royal, on Tudor Street, Sheffield, after the fire which destroyed it, in December 1935. It was built in 1773 on the site of The Assembly Rooms, was greatly enlarged in 1880, and in 1898 was partly reconstructed. The Lyceum Theatre can be seen to the left. | Picture Sheffield Photo: Picture Sheffield
12. Stocksbridge Congregational Church
Stocksbridge Congregational Church, on Manchester Road, Sheffield, pictured on November 16, 1921, after it was destroyed by fire | Picture Sheffield Photo: Picture Sheffield