From churches to pubs, nightclubs and sports venues, many notable landmarks across the city have been consumed by flames.
This retro photo gallery looks back at those sites, showing them before and after the fires struck.
Most of these landmarks were so badly damaged that they had to be demolished, while in other cases the charred shell was left standing, open to the elements.
The fires that destroyed these buildings include the largest ever peacetime conflagration in Sheffield, which broke out beside the railway tracks more than a century ago.
These nostalgic images show the lost landmarks inside and out, revealing the beautiful architecture and stunning interiors that are sadly no longer.
How many of these old landmarks do you remember?
17. Oak Street Chapel
The interior of Oak Street Chapel, Heeley, Sheffield, which was destroyed by fire in 1947 | Picture Sheffield/Harold Biggin Photo: Picture Sheffield/Harold Biggin
18. Loxley Chapel
Loxley Congregational Chapel, on Loxley Road, Sheffield, in 1905. It was gutted by fire in 2016. | Picture Sheffield/Furniss Photo: Picture Sheffield/Furniss