A quick count-up of the players expected to be unavailable for the Tigers battle comes to an eye-watering 12, meaning a swathe of changes from the Deepdale battle just a few days ago seems unlikely. Will Vaulks and Akin Famewo are expected to have joined the injury long-list after sustaining hamstring trouble while George Byers was sent off and will face a three-match suspension should an appeal not be upheld.
Much of the decision-making may well take place in the sports science department such is the need to keep things as fresh as possible and after a gruelling midwinter fixture schedule, Wednesday will have their work cut out to keep the intensity up.
That said, they've shown plenty of scrap with their Preston win a gleaming example. With caveats aplenty, here's a peek at the side we think Danny Rohl could name to take on Hull.
9. CAM - Josh Windass
Got some minutes at Deepdale to signal his return and looked in good nick. In an ideal world there may be appetite to offer another sub appearance but it's needs must in midfield. Could also take one of the attacking spots. | PA
10. RAM - Anthony Musaba
Didn't have his most sparkling outing on Friday but offered glimpses of what he can do. There's a few different ways Wednesday could go here in terms of how they line up their attack. | Steve Ellis
11. CF - Bailey Cadamarteri
Reported soreness post-match and he did look a little shot before he was given an early rest on Friday. With Windass back and Fletcher having performed well off the bench in recent outings there might be an opportunity to offer an overdue rest for the teenager - or they could continue riding the wave. | Steve Ellis
12. LAM - Djeidi Gassama
The third wheel in the Owls' youthful front three last time out, Gassama is very much a work in progress but may get another go at delivering a little something. Johnson could operate higher, Windass could slot in here. Who knows? | Steve Ellis