A quick count-up of the players expected to be unavailable for the Tigers battle comes to an eye-watering 12, meaning a swathe of changes from the Deepdale battle just a few days ago seems unlikely. Will Vaulks and Akin Famewo are expected to have joined the injury long-list after sustaining hamstring trouble while George Byers was sent off and will face a three-match suspension should an appeal not be upheld.
Much of the decision-making may well take place in the sports science department such is the need to keep things as fresh as possible and after a gruelling midwinter fixture schedule, Wednesday will have their work cut out to keep the intensity up.
That said, they've shown plenty of scrap with their Preston win a gleaming example. With caveats aplenty, here's a peek at the side we think Danny Rohl could name to take on Hull.
5. CB - Di'Shon Bernard
Should continue his spot in the centre of defence however they line up. Did well alongside Ihiekwe at Deepdale. | Getty Images
6. LB - Marvin Johnson
Rohl spoke about a preference for an attacking left-back against Cardiff and that's something Johnson provides. Depending on where it's decided he's best playing there could be a door open for Reece James here, but Johnson looks back to his best. | Steve Ellis
7. CM - Tyreeq Bakinson
Welcomed back in from the cold with back-to-back substitute appearances, Bakinson is short on match minutes but may well be required with the vast absences in midfield. Could Liam Palmer slot in here? Is Momo Diaby ready? Or will the gangly 25-year-old get his chance? | Steve Ellis
8. CM - Barry Bannan
One of a few to look a little leggy at moments of the brutal battle at Preston but got half an hour's rest and will be desperate to continue in midfield and pull strings. | Steve Ellis