Plymouth Argyle are the visitors to what looks set to be a sell-out Hillsborough and what is set up to be something of a classic.
The two sides have been the best sides in the division so far this season, the table tells us that, and some of the best players the third tier has to offer will be in display.
But how will Darren Moore choose to set up his Wednesday side? Will there be a temptation to draft in Aden Flint, or will he stick with the back three that has performed so strongly in recent weeks? What about George Byers and Barry Bannan – will they be drafted straight back in to midfield?
Here’s our stab at what the side will be as the Owls look to jump into first place.
9. LWB - Marvin Johnson
Is he an underappreciated figure in the Wednesday side? Defensively diligent, going forward he is a regular supplier of assists and attacking goodness. There's little alternative, to be fair, but Johnson is an understated key man in this outfit. Photo: Steve Ellis Steve Ellis
10. CF - Josh Windass
He's been excellent in the deeper number 10 role in recent weeks. If Moore decides one of the Byers / Bannan returnees should start from the bench, there'd be no problem Windass starting from midfield whatsoever. He has to start, having been gifted the January player of the month award, and has been a real source of attacking threat for a good while now. Will he start up top? Photo: Steve Ellis
11. CF - Michael Smith
Handed a beather for the Fleetwood game, Smith has been a solid performer for Wednesday this season and fulfils an important role at both ends of the pitch. There's one or two that can perform this role, but fresh of leg, Smith should be brought back in. Photo: Steve Ellis Steve Ellis