Plymouth Argyle are the visitors to what looks set to be a sell-out Hillsborough and what is set up to be something of a classic.
The two sides have been the best sides in the division so far this season, the table tells us that, and some of the best players the third tier has to offer will be in display.
But how will Darren Moore choose to set up his Wednesday side? Will there be a temptation to draft in Aden Flint, or will he stick with the back three that has performed so strongly in recent weeks? What about George Byers and Barry Bannan – will they be drafted straight back in to midfield?
Here’s our stab at what the side will be as the Owls look to jump into first place.
5. RWB - Jack Hunt
Solid stuff yet again from Hunt who is building a head of steam wide right for Wednesday. How big could his experience and the freshness in his legs be after a first half of the campaign sat twiddling his thumbs? In the face of a Plymouth side who can play a bit, his defensive skills could be as important as his ability to seize the moment and break forward. Photo: Steve Ellis
6. CM - Will Vaulks
A big part of the side now after a slow start to the campaign. Rugged, determined and with an-ever more impressive pass here and there, the Welsh international will be an important player in disrupting the Pilgrims' progress - and setting up a platform for those around him to work from. Photo: Steve Ellis Steve Ellis
7. CM - George Byers
Here comes the question - will Byers be ruled fit to feature alongside Bannan? Can you throw them both in together? There's no doubt Byers is a key man both defensively and offensively and compliments Vaulks and Bannan beautifully. If he is at 100%, surely he drops in? Photo: Steve Ellis Steve Ellis
8. CM - Barry Bannan
The main man. Wednesday have nursed his absence without a ripple, but again, if he's fit he has to play, doesn't he? There's a fair argument to suggest Vaulks, Byers, Bannan is Wednesday's most complete midfield three. He'll be chomping at the bit. Photo: Steve Ellis