It'll be the fourth time that Wednesday have faced the Sky Blues in 2023/24, losing their first two meetings before a late Djeidi Gassama goal at Hillsborough last month secured a replay for a spot in the fifth round.
Priorities may well have shifted for Wednesday after the heavy defeat to Huddersfield Town stuck a big dent in their survival hopes, and it may be that Danny Röhl now decides to rest players in midweek ahead of the huge game against Birmingham City on Friday night.
That could lead to full debut for Gui Siqueira after coming off the bench previously, and also offer a way in from the cold for players who have been out of favour lately.
If Röhl does go young, and make changes, then this is how the Owls could line up:
9. Mallik Wilks - RW
He's back fit again and looking to try and force his way into the manager's plans. Could be given a chance to do that after coming very close to getting the Owls' only goal against Huddersfield. | Steve Ellis / UGC
10. Ashley Fletcher - ST
Wednesday have a few that could play the sole striker role, but after missing out on the squad at Huddersfield it may be seen as time to bring him back in. | UGC / Steve Ellis
11. Djeidi Gassama - LW
Wednesday aren't exactly flush for wingers, so in this formation it's likely that either Gassama or Musaba will start, and the latter has played quite a lot of football this season. 'Gass' was great against Coventry last time, too. | UGC / Steve Ellis