It'll be the fourth time that Wednesday have faced the Sky Blues in 2023/24, losing their first two meetings before a late Djeidi Gassama goal at Hillsborough last month secured a replay for a spot in the fifth round.
Priorities may well have shifted for Wednesday after the heavy defeat to Huddersfield Town stuck a big dent in their survival hopes, and it may be that Danny Röhl now decides to rest players in midweek ahead of the huge game against Birmingham City on Friday night.
That could lead to full debut for Gui Siqueira after coming off the bench previously, and also offer a way in from the cold for players who have been out of favour lately.
If Röhl does go young, and make changes, then this is how the Owls could line up:
5. Reece James - LB
He came on against Huddersfield but it was quite late in the day. Röhl may look to give him a start - though it's been a while since that happened. | Ellis / UGC
6. Will Vaulks - CM
He's been in and out of the team lately, but this could be seen as an important game to bring Vaulks back into the fold. If they go young then his experience will be key. | UGC / Getty
7. Momo Diaby - CM
He's another who needs more minutes in his legs, and going on the idea that some could be rested then this feels like an ideal time to give him some. | UGC / Steve Ellis
8. Rio Shipston - CM
He came on in the FA Cup against Cardiff, and with others being rested or cup-tied it may be a chance for him to show Röhl what he's capable of. | UGC / Steve Ellis