The Magpies are flying high in the Premier League and boast a squad bang in form - unbeaten in 13 and with one of the best defensive records in the country.
We asked colleague Jordan Cronin, who covers Newcastle United for our sister title Newcastle World, for a heads-up on how Eddie Howe’s side could go about it.
Over to Jordan: “No disrespect to Wednesday but Eddie Howe is expected to ring the changes for the trip to Hillsborough given the game falls three days before the Carabao Cup last eight clash at home to Leicester.
“Ultimately, the Leicester game takes precedence as its the first time since 2006 Newcastle play a quarter-final at St James’ Park in front of supporters. That said, Howe has made it clear he wants to take every competition seriously and whatever starting XI he names will be expected to beat Wednesday.”
9. CM - Elliot Anderson
Repeatedly linked with a loan switch to Wednesday this summer - not that to our knowledge anything got remotely close on that front - Anderson is one of the more highly-rated young players in the country and reports have fired-up again linking him with a January move to S6. One to keep an eye out for. Photo: Stu Forster
10. LW - Allan Saint-Maximin
This would be an exciting one. Saint-Maximin hasn't been quite at the peak of his powers this season on account of injury but does sprinkle a bit of glamour on things with his entertaining playing style. Photo: Stu Forster
11. CF - Chris Wood
A proven Premier League front man who cost them £25m less than a year ago, New Zealand international Wood is another who would cause the Owls defence big problems if selected. Has two Premier League goals this season in what has been a bit-part effort mainly from the bench. Photo: George Wood
12. RW - Jacob Murphy
The return of Murphy should be hailed by Wednesday fans - in terms of what it was meant to achieve, it was one of the better ones in recent times. Murphy scored nine goals for the Owls in the 2019/20 season and became something of a fan favourite in a difficult campaign. Has been a near ever-present in recent weeks for the Magpies and is having an impressive year. Photo: Ian MacNicol