The Magpies are flying high in the Premier League and boast a squad bang in form - unbeaten in 13 and with one of the best defensive records in the country.
We asked colleague Jordan Cronin, who covers Newcastle United for our sister title Newcastle World, for a heads-up on how Eddie Howe’s side could go about it.
Over to Jordan: “No disrespect to Wednesday but Eddie Howe is expected to ring the changes for the trip to Hillsborough given the game falls three days before the Carabao Cup last eight clash at home to Leicester.
“Ultimately, the Leicester game takes precedence as its the first time since 2006 Newcastle play a quarter-final at St James’ Park in front of supporters. That said, Howe has made it clear he wants to take every competition seriously and whatever starting XI he names will be expected to beat Wednesday.”
5. CB - Sven Botman
A man mountain centre-half, 12-cap Dutch international Botman cost Newcastle somewhere in the region of £35m to swipe him from French club Lille last summer. He's been a key man for the Magpies this season, playing at the heart of defence on their current run of four clean sheets on the bounce. Photo: LINDSEY PARNABY
6. LB - Jamal Lewis
Former Norwich man Lewis has played as many international games for Northern Ireland as he has senior outings for his club this season - two apiece. Another who could come in for the rotation of the cup at left-back. Photo: Stu Forster
7. CM - Sean Longstaff
At one stage assumed to be one that might drop in and out of the side this season but very much a part of Howe's preferred XI having played in 18 of their 19 Premier League matches. Brother of Matty - out on loan at Colchester - who was briefly of interest to Wednesday in the summer. Photo: David Cannon
8. CM - Joe Willock
Another Premier League regular, former Arsenal man Willock has two league goals to his name this season and offers a definite goal threat from midfield. Photo: Julian Finney