While the Blades are flying high in the Premier League, their opponents are in danger of slipping into the second tier relegation scrap in the coming weeks. Here's a look back at the last five fixtures between the two sides, in a fixture which has always been rich in goals and drama over the years.
1. Sheffield United 4-0 Reading - February 2019
This result saw the Blades move into the automatic play-off spots last season, as they ripped the Royals to shreds at Bramall Lane. Kieron Freeman scored the opener after 38 seconds, and a Gary Madine brace saw United cruise home. (Photo by George Wood/Getty Images) Photo: George Wood
2. Reading 0-2 Sheffield United - December 2018
A dramatic finish saw United seal the win with two late goals. Billy Sharp scored the first, before George Baldock's brother, Sam, netted an own-goal; a moment that surely dominated their family Christmas dinner conversation. (Photo by Catherine Ivill/Getty Images) Photo: Catherine Ivill
3. Reading 1-3 Sheffield United - February 2018
Another big away win for the Blades, and this one saw Reading boss Jaap Stam sacked not long after. Mark Duffy scored an absolute rocket, as Sharp chipped in with a brace as United took all three points. (Photo by Catherine Ivill/Getty Images) Photo: Catherine Ivill
4. Sheffield United 2-1 Reading - October 2017
Billy Sharp was on the scoresheet here too, when he ended a rare goal drought stretching almost three months. Paul Coutts opened the scoring for United, while Royals winger Roy Beerens scored a late consolation goal for his side. (Photo by Nathan Stirk/Getty Images) Photo: Nathan Stirk