From the victory over West Brom in midweek, Ollie Norwood, Iliman Ndiaye, Conor Hourihane and the injured David McGoldrick drop out.
In come Sander Berge, John Fleck, Oli McBurnie and the returning Morgan Gibbs-White.
Blades: Foderingham, Bogle, Basham, Egan, Robinson, Baldock, Berge, Fleck, Gibbs-White, Sharp, McBurnie.
Subs: A. Davies, Norwood, Davies, Hourihane, Goode, Ndiaye, Jebbison.
Town have also made four changes.
Josh Ruffels, Pipa, Jon Russell and Josh Koroma come in.
Huddersfield: Nicholls, Pipa, Pearson, Lees, Ruffels, Thomas, Hogg, O'Brien, Russell, Koroma, Ward. Subs: Toffolo, Rhodes, Blackman, Holmes, Turton, Sinani, Eiting.
Referee: James Linington (Isle of Wight)