With United so well-placed in the race for promotion, some supporters insist they should focus on the league and forego any success in the cup. Others disagree, believing a run to the latter stages of the famous old competition can only help, rather than hinder, United's push for the Premier League.
Boss Paul Heckingbottom is not blessed with a plethora of options to choose from, with a number of key men in the treatment room, and it will be interesting to see how many changes the Blades chief makes for the trip to the National League promotion-chasers.
So we tasked our man to step into Heckingbottom's shoes and pick the side he would send out against Wrexham – how many selections would you agree with?
1. Adam Davies
Is certain to play barring any late hiccups, and as good as confirmed as such in his pre-match press conference. A good opportunity for some match practice and to attempt to catch the eye Photo: Paul Terry
2. Sai Sachdev
With George Baldock sidelined and Jayden Bogle so integral, there’s no way I’m risking him from the start at Wrexham. Sachdev has had a taste of first-team action and I’d be exposing him to some more Photo: Andrew Yates
3. Chris Basham
Did so well after coming in at Millwall and will be a good opportunity for him to shake off some more ring-rust for when, as is inevitable, he will be called upon between now and the end of the season Photo: Andrew Yates
4. John Egan
The lack of a natural replacement necessitates his presence on the teamsheet. If Ciaran Clark was fit I’d have played him in the centre but Egan gets the nod Photo: Danny Lawson