With United so well-placed in the race for promotion, some supporters insist they should focus on the league and forego any success in the cup. Others disagree, believing a run to the latter stages of the famous old competition can only help, rather than hinder, United's push for the Premier League.
Boss Paul Heckingbottom is not blessed with a plethora of options to choose from, with a number of key men in the treatment room, and it will be interesting to see how many changes the Blades chief makes for the trip to the National League promotion-chasers.
So we tasked our man to step into Heckingbottom's shoes and pick the side he would send out against Wrexham – how many selections would you agree with?
9. James McAtee
A very talented player with the enthusiasm of youth, it could be the kind of game for the Manchester City loanee to light up with his undoubted quality Photo: Lexy Ilsley
10. Billy Sharp
A lack of forward options, and a reluctance to risk Ndiaye for obvious reasons and Oli McBurnie until he is fully fit, means Sharp gets the nod for me. Still the best finisher at the football club and will back himself to tuck a chance away if one arises Photo: Andrew Yates
11. Daniel Jebbison
Was an almost certainty to start this game even before he scored the winner last time out against Hull, so deserves his run in the team to continue Photo: Andrew Yates