Click through our gallery to see if you can remember some real highs and lows for the Blades.
21. Blades photos from the noughties
Neil Warnock and Wigan manager Paul Jewell show contrasting emotions during the crunch Premier League clash between their sides at the Lane in May 2007. Wigan's 2-1 win coupled with West Ham United's 1-0 victory over Manchester United at Old Trafford condemned Warnock's men to relegation after a solitary season in the top flight. Photo: John Giles
22. Blades photos from the noughties
A young United fan shows his support for the club's former manager before the Coca-Cola Championship match against Crystal Palace - managed by Warnock - at Bramall Lane in December 2007. Photo: Ross Kinnaird
23. Blades photos from the noughties
A youthful-looking Billy Sharp celebrates one of his hat-trick goals against QPR in August 2008. Photo: PA Wire
24. Blades photos from the noughties
Kyle Walker sits dejectedly on the Wembley turf after United's Coca-Cola Championship play-off final defeat to Burnley in May 2009. Photo: Jamie McDonald