Click through our gallery to see if you can remember some real highs and lows for the Blades.
17. Blades photos from the noughties
Tense United players watch on during the penalty shoot-out against Arsenal at the end of the FA Cup fifth round replay at Bramall Lane in March 2005. Photo: Clive Brunskill
18. Blades photos from the noughties
United skipper Chris Morgan, his teammates and coaching staff celebrate promotion to the Premier League in April 2006. Photo: Nigel Roddis
19. Blades photos from the noughties
Neil Warnock congratulates stand-in goalkeeper Paul Jagielka after United beat Arsenal 1-0 at the Lane in December 2006. Photo: PAUL ELLIS
20. Blades photos from the noughties
Derek Geary fights for possession with Manchester United's Cristiano Ronaldo at Bramall Lane in November 2006. Photo: PAUL ELLIS