Bawtry Road in Brinsworth, Rotherham has been closed between Bonet Lane and Ackworth Lane following reports of a vehicle colliding with a house in the road in the early hours of the morning.
Police, ambulance and fire crews have all been at the scene.
The road is understood to be sealed off in both directions with diversions in place.
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Unconfirmed reports suggest that a Volkswagen Golf crashed into properties in Bawtry Road shortly after midnight last night.
It is understood the vehicle may have overturned in the incident.
Police forensic and crime investigation scene officers remain at the scene in Bawtry Road and are expected to remain throughout the morning.
Anyone with information about the incident should contact South Yorkshire Police on 101.