The man, in his 20s, was found conscious and breathing but in urgent need of medical attention when firefighters entered a burning flat on Blackstock Road, Gleadless Valley, at 5pm yesterday.
The property was well alight when crews arrived.
South Yorkshire Police said: "Officers attended a property on Blackstock Road in Sheffield at about 5pm yesterday.
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“The property was well alight and the Fire Service were also in attendance.
“Upon exploring the flat the Fire Service found a man conscious and breathing but in urgent need of medical attention.
“The Ambulance Service attended and transported the occupant, a man aged in his 20s, to hospital and his injuries are believed to be non-life threatening.
“The fire was extinguished by about 6.25pm and deemed to be accidental by the fire service and the flat was boarded up by the council.”