A fire broke out in a building on the corner of Attercliffe Road and Staniforth Road, Attercliffe, and at its height five fire engines were at the scene, as well as a turntable ladder to tackle the flames from above.
The fire is believed to involve a former bank, which was turned into a bar.
South Yorkshire Fire and Rescue said no injuries have been reported.
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The cause is not yet known.
More to follow.