United were close to their irresistible best at times in the first half and went ahead through striker Oli McBurnie’s header, his second in as many games.
A second early in the second half calmed any nerves, Anel Ahmedhodzic volleying home from a corner, before Iliman Ndiaye added a third to really seal the game.
Ahmedhodzic netted his second later on to put the gloss on his display as United returned to the top of the early Championship table.
Here’s how our man rated the Blades on another night to remember at the Lane ...
1. Luton, England, 26th August 2022. Wes Foderingham of Sheffield Utd leaves the game feeling ill during the Sky Bet Championship match at Kenilworth Road, Luton. Picture credit should read: David Klein / Sportimage
Wes Foderingham of Sheffield United went off with illness at Luton on Friday: David Klein / Sportimage Photo: David Klein
2. George Baldock 7
Another solid display down the right flank for the Blades man, which ended prematurely when he was replaced by Basham with around 12 minutes left. Hopefully that's just a precaution rather than anything injury-related, with Baldock being United's only fit senior right-back RESTRICTIONS: EDITORIAL USE ONLY No use with unauthorised audio, video, data, fixture lists, club/league logos or "live" services. Online in-match use limited to 120 images, no video emulation. No use in betting, games or single club/league/player publications. Photo: Tim Goode
3. Anel Ahmedhodzic 9
Came back into the side at Basham's expense and doubled United's lead in the second half with a true striker's finish, volleying home Doyle's corner in front of the Kop. Added a second for good measure and is taking to life as an attacking centre-back very nicely indeed. Top tackle late on to preserve the clean sheet too Photo: Simon Bellis
4. John Egan 7.5
Was indebted to his partner Norrington-Davies for bailing him out of trouble after a poor pass into midfield, and then a missed challenge, presented Reading with a superb chance to equalise in the first half. Recovered after that in fairness and the visitors didn't have much more of a sniff Photo: Andrew Yates