Ronnie Coleman, from Manor, was last seen at 3.10pm on City Road.
He is 5ft 6ins tall with shaved, blond hair.
A South Yorkshire Police spokesman said: "He hasn’t been seen or heard from since and officers are asking anyone who knows where he is to contact them.
"Police believe Ronnie may be wearing a blue and grey tracksuit and dark blue trainers.
"Ronnie is known to frequently visit the Manor and Richmond areas of Sheffield."
Call South Yorkshire Police on 101.