But there are many reasons to be optimistic about the city’s fortunes once the pandemic has eased and life has regained a little more normality.
Plans are still being made to open new venues and businesses, and some have even managed to launch in recent times despite all the upheavals of 2020.
Here are 12 places you can look forward to visiting.
In these confusing and worrying times, local journalism is more vital than ever. Thanks to everyone who helps us ask the questions that matter by taking out a digital subscription or buying a paper. We stand together. Nancy Fielder, editor.
5. True Loves
Waterside bar and delicatessen True Loves will open at Victoria Quays after lockdown. Situated in the archway next door to popular bar Dorothy Pax, its original launch date was set for April 2020. Its owner is Bally Johal, who also runs vintage shop Thrifty Store and bar Bal Fashions, both in nearby Castlegate. Photo: Push Sheffield
6. Age UK's Hillsborough Park café
The Age UK charity is restoring the derelict Grade II-listed coach house in Hillsborough Park to create a new community café, with the nearby potting shed set to become a space for activities. The aim is to open the £1 million dementia-friendly scheme in summer 2021. Photo: Submitted
7. From House of Fraser to Flannels
The House of Fraser department store at Meadowhall is to become a large Flannels outlet as part of a plan from Mike Ashley's Frasers Group. There will be areas focused on experiences - such as a beauty hall and a fitness studio. Photo: JPIMedia
8. Fred Aldous
Fred Aldous opened in Fitzalan Square in autumn but the quieter days of the pandemic mean some people may not have had chance to pay a visit to the shop yet - it's a much-loved family-run arts and crafts firm, with a vast range of products. Photo: Brian Eyre