The Chairboys, promoted to the second tier of English football for the first time in their history last summer, are second-from-bottom in the Sky Bet Championship and go into the game at Adams Park five points ahead of Garry Monk’s side.
And Saturday’s clash will be only the fifth time ever the two sides have come face-to-face in competitive football.
The last time the Owls made the trip south to deepest Buckinghamshire was nine years ago today when goals from Jose Semedo and Ryan Lowe helped secure a 2-1 win for the visitors, who would go on to pip arch rivals Sheffield United to a place in the Championship later that season.
So, let’s take a look at what happened to the side which starred for Wednesday on October 29, 2011.
1. Stephen Bywater
Bywater made 32 appearances for the Owls after joining initially on an emergency three-month deal as cover for injured number one Nicky Weaver in September 2011. He left Hillsborough for Millwall in June 2013 following the arrival of Chris Kirkland and later played for Gillingham, Doncaster Rovers and Indian outfit Kerala Blasters. He retired in June at the age of 39 after his release by Burton Albion.
Photo: Pete Norton
2. Danny Batth
Defender Batth had two spells at Wednesday at the end of the 2010/11 season and then for the entire campaign in 2011/12. He scored two goals in 54 outings for the Owls. He played more than 200 times for Wolverhampton Wanderers before he was deemed surplus to requirements at Molineux when they made their successful return to the Premier League. Initially loaned out to Middlesbrough, he has since made a permanent move to Stoke.
Photo: Gareth Copley
3. Lewis Buxton
Hugely-popular Buxton remained at Wednesday until 2015 when he joined Rotherham, keeping the Millers in the Championship. He was then released and joined Bolton and spent a season with the Trotters before calling it quits.
Photo: Laurence Griffiths
4. Mark Reynolds
Scottish defender Reynolds arrived at Hillsborough in January 2011 from Motherwell and immediately set about impressing Wednesdayites by declaring how signing for the club was 'easy' when 20,000 fans turn up for League One games. However, Reynolds only played 10 times for the Owls and returned north of the border with Aberdeen in 2013. He spent six years with the Dons and is now turning out for Dundee United, where he is skipper.
Photo: Steve Ellis