Last time the two sides met, Wednesday successfully shut out the Hornets' formidable attacking unit in a goalless draw at Hillsborough, and they'll be hoping for a similarly resilient defensive performance against the promotion-chasing side this time around.
As things stand, the Owls are six points from safety, but do have a precious game in hand over 21st place Birmingham City, who recently brought former player Lee Bowyer in as manager.
Speaking ahead of the weekend, Wednesday coach Paul Williams, who has recently joined the club alongside manager Darren Moore, revealed: "We’ve worked really hard. I think the lads are responding to what how the manager wants things to be done, it’s been an upward spiral and I think results have shown that in the last couple of games.
“We came in and there were games every two or three days.
“We’ve worked really hard in this international break and we’re putting down fundamentals of how we want to play. Hopefully that’ll put us in good stead for the rest of the season.”
Here are today's biggest transfer stories and the latest team news involving Sheffield Wednesday and the rest of the Championship, as the build-up to the upcoming weekend's action continues:
1. Bellingham discusses Man Utd snub
Ex-Birmingham City wonderkid Jude Bellingham has revealed he never considered a move to Manchester United, and was determined to join Borussia Dortmund as soon as they expressed an interest. He's made 35 appearances for BVB this season. (FourFourTwo) Photo: ADRIAN DENNIS
2. Bluebirds loanee up for grabs this summer
Cardiff City loan star Harry Wilson looks set to be up for grabs this summer, as Liverpool prepare to move on a number of their fringe players. He's likely to be sold for less than their original asking price of £20m. (Mirror) Photo: JOHN THYS
3. Hornets could keep Lazaar
Watford sporting director Cristiano Giaretta has revealed he's held talks with short-term signing Achraf Lazaar over the potential of extending his contract with the Hornets, but no concrete decision will be made until the summer. (Watford Observer) Photo: Alex Morton
4. Leeds among Dike's admirers
Barnsley's star loanee Daryl Dike is rumoured to have caught the eye of Leeds United, West Ham and Chelsea. The 20-year-old Orlando City striker has excelled since joining the Tykes on loan, scoring five goals in 11 games. (Team Talk) Photo: Clive Rose