Illness and injury has forced Monk into making two alterations to his defence and midfield.
Tom Lees, fit-again following a lengthy spell on the sidelines with a hamstring problem, returns at centre-half as fans' favourite Julian Börner misses out due to a virus. It is club captain Lee's first outing since Preston North End on August 24.
Sam Hutchinson is not involved because of a calf problem while Joey Pelupessy and Adam Reach have dropped to the bench.
Monk has selected Jacob Murphy out wide, restored Barry Bannan to midfield and handed a first-team recall to Atdhe Nuhiu. It appears he has switched from a 4-3-3 formation to 4-4-2, with Nuhiu partnering top-scorer Steven Fletcher in attack.
Striker Jordan Rhodes, fresh from scoring in the Under-23s draw with Burnley last week, is preferred to Sam Winnall on the bench.
Owls: Westwood; Palmer, Lees, Iorfa, Fox; Murphy, Bannan, Lee, Harris; Fletcher, Nuhiu. Substitutes: Dawson, Rhodes, Pelupessy, Thorniley, Reach, Odubajo, Forestieri.