Daunting? That's not the feeling we took from pre-match press conferences with Bailey Cadamarteri and Danny Röhl as the Owls plot a positive result and their third away win of the campaign. They'll face a team in the aforementioned form and with a promotion race to contend with, but have confidence of their own as they ride high in the Championship form table in their own right.
There are absences for midfield trio Will Vaulks, George Byers and Jeff Hendrick while Callum Paterson's absence through concussion protocol continues. Juan Delgado and Dominic Iorfa continue their rehab from long-term problems but otherwise there is a full squad to choose from.
There are big decisions to be made in set-up and selection. Will James Beadle jump straight in between the sticks? Will Bambo Diaby jump back into the middle of defence after his suspension?
We've had a red hot crack at selecting a side that could line up on Saturday.
5. LB - Akin Famewo
Defensively sound and increasingly explosive going forward, Famewo has proven himself to be a Rohl favourite and has offered the performances to show for it. Photo: Steve Ellis
6. CDM - Liam Palmer
With Momo Diaby getting back to speed, it'll be interesting to see what happens to Palmer, who has been excellent in his revert to midfield. We've gone for both here. With Will Vaulks out for a few weeks, there's room for both of them to play a role. | Steve Ellis
7. CDM - Momo Diaby
We've gone for what the kids call a 'double pivot' for Southampton. Diaby has been building his fitness and has been given pointers by Rohl as to how best to get upto speed with how they want to play. Another week in training, he could start this one. | Steve Ellis
8. CM - Barry Bannan
At the heart of what Wednesday do best, skipper Bannan is a near-certain starter. Contributes both with and without the ball and with two midfielders behind him can be pushed a little higher to start counter attacks. | Steve Ellis