Millwall could be without three players this weekend when Sheffield Wednesday visit the Lions at The Den.

The Owls take on Alex Neil’s men on Wednesday as they look to try and bounce back from the 3-0 defeat the hands of bitter rivals, Sheffield United, on Sunday, and are waiting to hear whether Dominic Iorfa will be available for selection after he was forced off during the loss at Hillsborough.

Three Millwall players could miss out vs Sheffield Wednesday

And things didn’t go much better for Millwall, either, as they fell to a 3-1 defeat to Portsmouth at Fratton Park, a game that also saw them have a man sent off and two others forced off due to concussion and injury. Two of them - Joe Bryan and Zak Sturge - will definitely miss out, while Derek Mazou-Sacko is also a doubt after he was unable to finish the game.

Bryan’s red card made it difficult for the visitors to forge a fightback against Pompey, and Sturge’s absence with a head injury means that he’ll have to follow FA protocols on concussion injuries before he’s able to return. Mazou-Sacko’s absence against the Owls isn’t certain, meanwhile, however his manager did say after the weekend’s defeat that ‘it’s not looking good’.

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On the game itself, Neil said, “Today's a real disappointment but we've had to overcome a lot of challenges," Neil told the media after the game. The nature of the goals, particularly the second and the third for me, were extremely frustrating because I thought we should have done better.

"I think it's very dubious for the sending-off but Joe should not give them the opportunity to do that. I think the reaction of the players, the reaction of the fans, it doesn't surprise me that the referee's got out the red card.

"I know it sounds like excuses but I've been at this level a long time and when you are depleted in so many different areas and you're missing your captain, it's really difficult to win games at this level and that was a hard day for us today."

Henrik Pedersen and his players face Millwall at 7:45pm on Wednesday night, with the away side looking to end their lengthy run of games without a victory.