The Owls had the better of the possession, but were unable to find goalscoring opportunities, and registered just one shot on target across the duration of the game.
Speaking after the loss, caretaker manager Neil Thompson claimed his side are determined to bounce back this weekend, and said: "We’ve all got to be strong, everybody at the club, to get us back on the right track.
"This is football, you have these challenges when you get beat."
"We haven’t got too much time to think about it because we’re back down here to Luton. I thought in general we had a positive response from the weekend, but you’re playing against a top, top team in this division. They can hurt you, and they did tonight."
Wednesday are back in action on Saturday afternoon, when they take on Luton Town - a side ten points above the Owls in the table, who have beaten them 1-0 in their last two meetings.
Here are today's biggest transfer stories and the latest team news involving Sheffield Wednesday and the rest of the Championship, following an action-packed couple of days of midweek action:
"This is football, you have these challenges when you get beat."
5. Wycombe new boy heads back out on loan
Wycombe Wanderers have loaned summer signing Giles Phillips back to Aldershot Town on a month deal, as the National League gears up for his return. He joined the club following a successful loan spell, after being released by QPR. (Club website)
Photo: Lewis Storey
6. Bayern leading Aarons race
Bayern Munich are believed to be leading the race to sign the race to sign Norwich City's Max Aarons. Everton and Man Utd are also keen, but the Bundesliga side are thought to have already opened talks over a potential £40m deal. (Eurosport)
Photo: Julian Finney
7. Terriers win race for Sanogo
Huddersfield Town have won the race to sign free agent striker Yaya Sanogo. The ex-Arsenal and Toulouse striker has been looking for a new club since leaving Ligue 1 at the end of last season, and was also linked with Middlesbrough. (Club website)
Photo: REMY GABALDA
8. Race heats up for Celtic job
Ex-Bournemouth boss Eddie Howe and former Swansea manager Roberto Martinez are among the bookies' early favourites for the Celtic job. Caretaker boss John Kennedy and Chelsea icon Frank Lampard are among the front-runners. (SkyBet)
Photo: Ian MacNicol