The centre-half last featured for the Owls in their 1-1 home draw with Lincoln City last month and is one of several defenders in the treatment room at current alongside the likes of Sam Hutchinson and Lewis Gibson.
Iorfa was initially believed to have sustained a knock to his ankle.
But The Star has reason to believe Iorfa is suffering from a fresh but unconfirmed injury and that while an exact return date is not yet known, there are fears within the club it looks likely rule him out of action for several weeks.
Owls boss Darren Moore told the media after Tuesday’s Papa Johns Trophy clash win over Harrogate Town that he expected to be able to offer an update on Iorfa’s condition later this week after conversations with the club’s medical team and Iorfa himself.
The news is a blow to Iorfa, who spent the second half of last season on the sidelines having ruptured his achilles tendon just before Christmas.
With Sam Hutchinson and Lewis Gibson also out, Iorfa’s injury may well open up an opportunity for youngster Ciaran Brennan, who alongside fellow rookies David Agbontohoma and Jaden Brown impressed against Harrogate. Brennan is back training with the first team having returned from a loan stint with Notts County.
“He's the more experienced of the three,” Moore said on Brennan. “But all three of them, particularly with the magnitude of the game, they were really pleasing.
“In the short term they're in training with us in the first team and he has to pit their wits against the first team. I'll take a look at them and if not we'll look at another loan at a more senior standard in terms of where they go. Ultimately we want them playing senior football. They're at that age now and tonight was perfect for them.
“There might be one or two clubs here watching tonight and we might get some offers for a loan, but it would have to be the right club for them. If we don't feel it is the right loan we'll keep them in the building with us, training with the first team.”