Last time the two sides met, Wednesday successfully shut out the Hornets' skilled attacking unit in a goalless draw at Hillsborough, and they'll be hoping for a similarly resilient defensive performance against the promotion-chasing side this time around.
As things stand, the Owls are six points from safety, but do have a game in hand over 21st place Birmingham City, who have appointed former player Lee Bowyer as their new manager in a bid to boost their survival hopes.
Speaking ahead of the weekend, Wednesday coach Paul Williams, who has recently joined the club alongside manager Darren Moore, revealed: "We’ve worked really hard. I think the lads are responding to what how the manager wants things to be done, it’s been an upward spiral and I think results have shown that in the last couple of games.
“We came in and there were games every two or three days.
“We’ve worked really hard in this international break and we’re putting down fundamentals of how we want to play. Hopefully that’ll put us in good stead for the rest of the season.”
Here are today's biggest transfer stories and the latest team news involving Sheffield Wednesday and the rest of the Championship, as the build-up to the upcoming weekend's action continues:
1. Ex-Blues man could land Bellingham fortunte
Ex-Birmingham City academy manager Kristjaan Speakman is rumoured to be due a whopping £700k for his role in negotiating Jude Bellingham's move to Borussia Dortmund. The 17-year-old picked up his second senior England cap last week. (Football Insider)
Photo: ADRIAN DENNIS
2. Warnock hints at lack of leaders at Boro
Middlesbrough boss Neil Warnock has admitted his side doesn't boast the dressing room leaders he had at his disposal during his time at Cardiff, citing Sean Morrison and Aron Gunnarsson as characters he could do with. (The 72)
Photo: Jacques Feeney
3. Rotherham linked with in-form striker
Rotherham United have been linked with a move for Boreham Wood striker Kabongo Tshimanga. He's netted 24 goals over the course of the last two seasons, and could be set for a move up the football pyramid. (Football League World)
Photo: George Wood
4. Boro fined for Swansea showdown
Middlesbrough have been hit with a £10k fine after their manager and some players confronted referee Gavin Ward following a controversial decision in their 1-0 loss to Swansea earlier in the month. Warnock has also been fined £7k. (BBC Sport)
Photo: Dan Istitene