Garry Monk's side begin the 2020/21 campaign in tough circumstances after being charged by the EFL in July – resulting in a points deduction.
But do the bookies believe Wednesday can avoid relegation? Scroll and click through the pages to find out:
17. Birmingham City
Odds to be relegated from the Championship: 11/2 Photo: Ross Kinnaird
18. Bristol City
Odds to be relegated from the Championship: 5/1 Photo: Jan Kruger
19. Queens Park Rangers
Odds to be relegated from the Championship: 9/2 Photo: Warren Little
20. Reading
Odds to be relegated from the Championship: 7/2 Photo: Naomi Baker