Garry Monk's side begin the 2020/21 campaign in tough circumstances after being charged by the EFL in July – resulting in a points deduction.
But do the bookies believe Wednesday can avoid relegation? Scroll and click through the pages to find out:
9. Preston North End
Odds to be relegated from the Championship: 16/1 Photo: Ross Kinnaird
10. Millwall
Odds to be relegated from the Championship: 14/1 Photo: Warren Little
11. Middlesbrough
Odds to be relegated from the Championship: 12/1 Photo: Alex Livesey
12. Derby County
Odds to be relegated from the Championship: 11/1 Photo: Alex Livesey