Here's a look at the Owls team the last time they managed to secure victory away at Bolton Wanderers, when they won 1-0 on 26 December 2012 - will Steve Bruce's men manage it on Tuesday night? Click and scroll through the images to see the team...
The Owls 'keeper made 84 league appearances in his time at the club.
The Owls defender also played for Wanderers later in his career.
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Johnson made 75 league appearances for Wednesday.
Wednesday was Gardner's last club before retiring - he also played for Crystal Palace, Hull, Everton and Port Vale.
Llera scored ten goals during his Owls career.
Antonio scored 17 goals in his Wednesday career.
McCabe made 30 appearances after joining Wednesday on a free from Rangers.
Lee is the only player who started in 2012 who is still in the Owls squad.
Helan signed for Wednesday in 2013 after two loan spells at the club.
The Sky pundit scored three league goals while playing for Wednesday.
The striker scored the only goal of the game while on loan from Stoke.
The defender came on as a sub for Wednesday, and has also played for Sheffield United and current club Rotherham United.
Another sub from Wednesday's last win at Bolton, Johnson signed for Wednesday for 500,000 from Bradford City.
O'Grady has played for 16 different clubs in his career and is currently at Oldham.