Warren Clarke, Cameron McCulloch, Freddie Nielsen, Connor O’Grady, Dan Wallis, Liam Williams and Eyad Hammoud will depart following the conclusion of the 2018/19 season.
Defender Nielsen, who joined Wednesday from Nottingham Forest’s youth set up, made five first-team appearances while O'Grady featured on two occasions.
Fellow Under-23s players Clarke, McCulloch, Wallis and Williams never made a senior outing while U18s striker Hammoud is leaving following the end of his scholarship.