Darren Moore’s men come up against Charlton Athletic on Saturday afternoon, and will be aiming to get their promotion hopes off to a positive start with a win.
Last season, the Owls beat Cardiff City by a single goal in the opening match of their Championship campaign, but how are they likely to get on this time around?
The boffins at Bookmakers.tv have been flicking back through the history books to see how every League One club have fared on their 10 most recent opening day outings, and we’ve compiled a league table showcasing the results.
Will it be a positive return to action in the third tier for Moore’s side, or will it be disappointment at the first hurdle?
Click and scroll through the pages below to read our countdown of all the standings...
1. Plymouth Argyle - 24th
Won: 3 Drawn: 1 Lost: 6 Goal Difference: -3 Points: 7 (Photo by Harry Trump/Getty Images) Photo: Harry Trump
2. Burton Albion - 23rd
Won: 2 Drawn: 2 Lost: 6 Goal Difference: -6 Points: 8 (Photo by Michael Regan/Getty Images) Photo: Michael Regan
3. Sunderland - 22nd
Won: 1 Drawn: 6 Lost: 3 Goal Difference: -3 Points: 9 (Photo by Stu Forster/Getty Images) Photo: Stu Forster
4. Crewe Alexandra - 21st
Won: 2 Drawn: 3 Lost: 5 Goal Difference: -3 Points: 9 (Photo by Charlotte Tattersall/Getty Images) Photo: Charlotte Tattersall