The Owls have been in dire form of late, and have lost their last six Championship matches on the bounce.
That slump has left them seven points adrift of safety with 12 games left to play.
Wednesday were beaten 3-0 by Reading in their most recent outing last weekend.
By contrast, Norwich are sitting pretty at the top of the table.
The Canaries are 10 points clear at the summit, and have won their last seven matches in the league.
Their most recent victory came against Luton Town last weekend, with Teemu Pukki and Todd Cantwell sharing the goals in a 3-0 win.
And Prutton predicts a similarly dominant performance this time out.
The pundit predicts that Wednesday will lose this one 2-0.