Monk, whose side are chasing a fourth consecutive away win in all competitions, has handed first-team recalls to Dominic Iorfa, Barry Bannan and Atdhe Nuhiu.
Tom Lees, Sam Hutchinson and Jordan Rhodes have dropped out of the starting XI.
Hutchinson misses out with a foot injury sustained in Friday's FA Cup victory over Queens Park Rangers while Massimo Luongo is unavailable for selection due to a groin strain.
Full-back Liam Palmer and forward Fernando Forestieri are not involved and 12-goal leading scorer Steven Fletcher (knee) is a long-term injury casualty.
Wednesday, lying in 10th position, four points outside of the play-off zone, have beaten Wigan in six out of their last seven meetings.
Owls: Dawson; Odubajo, Iorfa, Borner, Fox; Murphy, Bannan, Pelupessy, Harris; Winnall, Nuhiu. Substitutes: Wildsmith, Urhoghide, Reach, Rhodes, Borukov, Hunt.