However, one pundit believes there is an opportunity to cause an upset in South Yorkshire, thanks to the Reds’ starting eleven.
Liverpool start at Bramall Lane with Adrian on goal after Allison suffered the sad and shocking loss of his father in Brazil last week.
And injuries meant they began with Nat Phillips and Ozan Kaback as the central defensive pairing – partnering each other for the first time.
It’s that which Graeme Souness believes could give Chris Wilder’s side hope.
Souness told Sky Sports: “You want your goalkeeper and your back fou or back three - especially your two centre backs - to be a unit themselves.
"They get an understanding and that grows and then you become effective if they are good enough.
"For Liverpool to be going into this game with three, two untried centre halves on a regular basis at this level and a goalkeeper who cam;t be coming into the game full of confidence, Sheffield United will see this as a wonderful opportunity.”