A Gareth Bale hat-trick and a Son Heung-Min strike were enough to hand Spurs all three points, and to make it four defeats out of five for the Blades.
Interim boss Paul Heckingbottom pulled no punches after the final whistle either.
Speaking about his side’s dire display, he said: “It’s anger at the first-half performance.
“I didn’t enjoy watching that. It was a passive performance. There was a difference in the second half, in approach and attitude.
“From Spurs’ point of view they’ll be happy with the goals but we’re not.
“The first is so passive, the second is a counter from our corner and the third is a giveaway in a bad area.
“We know he [Bale] is a world class player bit we can’t afford to give that type of player those opportunities. We have to be at our best to compete at this level.”
He added: “We know we’ve played against good players ever week in this league and we have to be at our best to compete, and we weren’t in the first half.
“That was the bit that upset me, to be honest. The first half wasn’t good enough.”
Next up for the Blades is a clash against Crystal Palace at Bramall Lane on Saturday afternoon.
We’ve gathered the best of today’s Premier League transfer rumours involving Sheffield United and the rest of their top flight rivals below...
1. Clarets keen on Worrall
Burnley, West Ham, and Norwich City are all keen on signing Nottingham Forest defender Joe Worrall. (The Sun) (Photo by Laurence Griffiths/Getty Images)
Photo: Laurence Griffiths
2. Tagliafico interest emphasised
Leeds United's interest in Ajax's Nicolas Tagliafico is ‘more serious than everyone assumed’. (De Telegraaf) (Photo by STEFAN WERMUTH/AFP via Getty Images)
Photo: STEFAN WERMUTH
3. Kent speaks out on Rangers future
Ryan Kent has spoken out on his future at Rangers amid reported interest from Leeds United. He said: "It's nice to be linked with other football clubs, the big clubs, but you've got to understand the duty of where you're at and as long as I'm at Rangers I'll always give 100 per cent to the club." (Sky Sports) (Photo by Ian MacNicol/Getty Images)
Photo: Ian MacNicol
4. Hammers make approach for Bissouma
West Ham have approached Brighton with an enquiry about midfielder Yves Bissouma ahead of the summer transfer window. (Sunday People) (Photo by Mike Hewitt/Getty Images)
Photo: Mike Hewitt